Cytosolic iron-sulfur assembly component 3
Definition:
Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect.
References:
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[1]. Daisheng Song, et al. A role for IOP1 in mammalian cytosolic iron-sulfur protein biogenesis. J Biol Chem. 2008 Apr 4;283(14):9231-8. [Content Brief]
[2]. Jianhe Huang, et al. IOP1, a novel hydrogenase-like protein that modulates hypoxia-inducible factor-1alpha activity. Biochem J. 2007 Jan 1;401(1):341-52. [Content Brief]
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