DCN1-like protein 5

Definition:

Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which is necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs). May play a role in DNA damage response and may participate in cell proliferation and anchorage-independent cell growth.

References:

[1]. Wei Guo, et al. In vitro biological characterization of DCUN1D5 in DNA damage response. Asian Pac J Cancer Prev. 2012;13(8):4157-62. [Content Brief]

[2]. Matthew J Keuss, et al. Characterization of the mammalian family of DCN-type NEDD8 E3 ligases. J Cell Sci. 2016 Apr 1;129(7):1441-54. [Content Brief]

[3]. Nathalie Meyer-Schaller, et al. The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12365-70. [Content Brief]

[4]. Claire C Bommeljé, et al. Oncogenic function of SCCRO5/DCUN1D5 requires its Neddylation E3 activity and nuclear localization. Clin Cancer Res. 2014 Jan 15;20(2):372-81. [Content Brief]

[5]. Julie K Monda, et al. Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes. Structure. 2013 Jan 8;21(1):42-53. [Content Brief]

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