DNA-dependent protein kinase catalytic subunit

[1]. T Carter, et al. A DNA-activated protein kinase from HeLa cell nuclei. Mol Cell Biol. 1990 Dec;10(12):6460-71. [Content Brief]

[2]. S Y Shieh, et al. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell. 1997 Oct 31;91(3):325-34. [Content Brief]

[3]. Hsin Ling Hsu, et al. Defining interactions between DNA-PK and ligase IV/XRCC4. DNA Repair (Amst). 2002 Mar 28;1(3):225-35. [Content Brief]

[4]. Xiaona Sun, et al. DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity. Nat Commun. 2020 Dec 3;11(1):6182. [Content Brief]

[5]. Siyu Chen, et al. Structural basis of long-range to short-range synaptic transition in NHEJ. Nature. 2021 May;593(7858):294-298. [Content Brief]

[6]. Yunmei Ma, et al. A biochemically defined system for mammalian nonhomologous DNA end joining. Mol Cell. 2004 Dec 3;16(5):701-13. [Content Brief]

[7]. D W Chan, et al. DNA-dependent protein kinase phosphorylation sites in Ku 70/80 heterodimer. Biochemistry. 1999 Feb 9;38(6):1819-28. [Content Brief]

[8]. Zhengping Shao, et al. DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis. Nature. 2020 Mar;579(7798):291-296. [Content Brief]

[9]. Mukesh Kumar Sharma, et al. In cellulo phosphorylation of XRCC4 Ser320 by DNA-PK induced by DNA damage. J Radiat Res. 2016 Mar;57(2):115-20. [Content Brief]

[10]. Thomas Wechsler, et al. DNA-PKcs function regulated specifically by protein phosphatase 5. Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1247-52. [Content Brief]

[11]. Nicolas Lévy, et al. XRCC1 is phosphorylated by DNA-dependent protein kinase in response to DNA damage. Nucleic Acids Res. 2006 Jan 5;34(1):32-41. [Content Brief]

[12]. S Jin, et al. Double-strand break repair by Ku70 requires heterodimerization with Ku80 and DNA binding functions. EMBO J. 1997 Nov 17;16(22):6874-85. [Content Brief]

[13]. Y Ariumi, et al. Suppression of the poly(ADP-ribose) polymerase activity by DNA-dependent protein kinase in vitro. Oncogene. 1999 Aug 12;18(32):4616-25. [Content Brief]

[14]. Yuhui Jiang, et al. Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation. Nat Cell Biol. 2015 Sep;17(9):1158-68. [Content Brief]

[15]. U Yavuzer, et al. DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D. Genes Dev. 1998 Jul 15;12(14):2188-99. [Content Brief]

[16]. S Iijima, et al. DNA-activated protein kinase in Raji Burkitt's lymphoma cells. Phosphorylation of c-Myc oncoprotein. Eur J Biochem. 1992 Jun 1;206(2):595-603. [Content Brief]

[17]. Sébastien Soubeyrand, et al. Threonines 2638/2647 in DNA-PK are essential for cellular resistance to ionizing radiation. Cancer Res. 2003 Mar 15;63(6):1198-201. [Content Brief]

[18]. Tarren Reitsema, et al. DNA-PK is responsible for enhanced phosphorylation of histone H2AX under hypertonic conditions. DNA Repair (Amst). 2005 Sep 28;4(10):1172-81. [Content Brief]

[19]. Ali Reza Amiri Moghani, et al. In cellulo phosphorylation of DNA double-strand break repair protein XRCC4 on Ser260 by DNA-PK. J Radiat Res. 2018 Nov 1;59(6):700-708. [Content Brief]

[20]. Fei Wang, et al. Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS. Mol Cell. 2022 Jun 2;82(11):2032-2049.e7. [Content Brief]

[21]. Yaping Yu, et al. DNA-PK and ATM phosphorylation sites in XLF/Cernunnos are not required for repair of DNA double strand breaks. DNA Repair (Amst). 2008 Oct 1;7(10):1680-92. [Content Brief]

[22]. Yaping Yu, et al. DNA-PK phosphorylation sites in XRCC4 are not required for survival after radiation or for V(D)J recombination. DNA Repair (Amst). 2003 Nov 21;2(11):1239-52. [Content Brief]

[23]. Mehdi Morchikh, et al. HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex that Regulates DNA-Mediated Innate Immune Response. Mol Cell. 2017 Aug 3;67(3):387-399.e5. [Content Brief]

[24]. Eun-Jung Park, et al. DNA-PK is activated by nucleosomes and phosphorylates H2AX within the nucleosomes in an acetylation-dependent manner. Nucleic Acids Res. 2003 Dec 1;31(23):6819-27. [Content Brief]

[25]. A J Bannister, et al. c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif. Nucleic Acids Res. 1993 Mar 11;21(5):1289-95. [Content Brief]

[26]. S H Liu, et al. The carboxyl-terminal transactivation domain of human serum response factor contains DNA-activated protein kinase phosphorylation sites. J Biol Chem. 1993 Oct 5;268(28):21147-54. [Content Brief]

[27]. Yunmei Ma, et al. Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Cell. 2002 Mar 22;108(6):781-94. [Content Brief]

[28]. Suisheng Zhang, et al. DNA-dependent protein kinase (DNA-PK) phosphorylates nuclear DNA helicase II/RNA helicase A and hnRNP proteins in an RNA-dependent manner. Nucleic Acids Res. 2004 Jan 2;32(1):1-10. [Content Brief]

[29]. Kyung-Jong Lee, et al. Identification of DNA-PKcs phosphorylation sites in XRCC4 and effects of mutations at these sites on DNA end joining in a cell-free system. DNA Repair (Amst). 2004 Mar 4;3(3):267-76. [Content Brief]

[30]. Ting-Hsiang Huang, et al. The Histone Chaperones ASF1 and CAF-1 Promote MMS22L-TONSL-Mediated Rad51 Loading onto ssDNA during Homologous Recombination in Human Cells. Mol Cell. 2018 Mar 1;69(5):879-892.e5. [Content Brief]

[31]. Parimal Karmakar, et al. Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation. J Biol Chem. 2002 May 24;277(21):18291-302. [Content Brief]

[32]. Caroline Schild-Poulter, et al. Down-regulation of histone H2B by DNA-dependent protein kinase in response to DNA damage through modulation of octamer transcription factor 1. Cancer Res. 2003 Nov 1;63(21):7197-205. [Content Brief]

[33]. S P Lees-Miller, et al. The human double-stranded DNA-activated protein kinase phosphorylates the 90-kDa heat-shock protein, hsp90 alpha at two NH2-terminal threonine residues. J Biol Chem. 1989 Oct 15;264(29):17275-80. [Content Brief]

[34]. H Niu, et al. Mapping of amino acid residues in the p34 subunit of human single-stranded DNA-binding protein phosphorylated by DNA-dependent protein kinase and Cdc2 kinase in vitro. J Biol Chem. 1997 May 9;272(19):12634-41. [Content Brief]