E3 ubiquitin ligase TRAF3IP2

Definition:

E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling. Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein. Essential adapter molecule in IL17A-mediated signaling. Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways.

References:

[1]. Caini Liu, et al. Act1, a U-box E3 ubiquitin ligase for IL-17 signaling. Sci Signal. 2009 Oct 13;2(92):ra63. [Content Brief]

[2]. Xiaoyuan Lin, et al. ORF8 contributes to cytokine storm during SARS-CoV-2 infection by activating IL-17 pathway. iScience. 2021 Apr 23;24(4):102293. [Content Brief]

[3]. Bertrand Boisson, et al. An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis. Immunity. 2013 Oct 17;39(4):676-86. [Content Brief]

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