Exonuclease V

Definition:

Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity.

References:

[1]. Justin L Sparks, et al. Human exonuclease 5 is a novel sliding exonuclease required for genome stability. J Biol Chem. 2012 Dec 14;287(51):42773-83. [Content Brief]

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