Fatty acyl-CoA reductase 1

Definition:

Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. It plays an essential role in the production of ether lipids/plasmalogens which synthesis requires fatty alcohols. In parallel, it is also required for wax monoesters production since fatty alcohols also constitute a substrate for their synthesis (By similarity).

References:

[1]. Masanori Honsho, et al. Topogenesis and homeostasis of fatty acyl-CoA reductase 1. J Biol Chem. 2013 Nov 29;288(48):34588-98. [Content Brief]

[2]. Masanori Honsho, et al. Posttranslational regulation of fatty acyl-CoA reductase 1, Far1, controls ether glycerophospholipid synthesis. J Biol Chem. 2010 Mar 19;285(12):8537-42. [Content Brief]

[3]. Sacha Ferdinandusse, et al. An autosomal dominant neurological disorder caused by de novo variants in FAR1 resulting in uncontrolled synthesis of ether lipids. Genet Med. 2021 Apr;23(4):740-750. [Content Brief]

[4]. Jeffrey B Cheng, et al. Mammalian wax biosynthesis. I. Identification of two fatty acyl-Coenzyme A reductases with different substrate specificities and tissue distributions. J Biol Chem. 2004 Sep 3;279(36):37789-97. [Content Brief]

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