Haptoglobin-related protein

Definition:

Primate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL). This HDL particle, termed trypanosome lytic factor-1 (TLF-1), mediates human innate immune protection against many species of African trypanosomes. Binds hemoglobin with high affinity and may contribute to the clearance of cell-free hemoglobin to allow hepatic recycling of heme iron.

References:

[1]. Marianne Jensby Nielsen, et al. Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein. Blood. 2006 Oct 15;108(8):2846-9. [Content Brief]

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