Hereditary prostate cancer

Definition:

Hereditary prostate cancer (HPC) has been used to characterize families with a particularly strong history of prostate cancer and includes those families with either: three or more affected first-degree relatives, prostate cancer diagnosed in three successive generations of the same lineage, or two first-degree relatives both diagnosed with early-onset disease. Familial cancer loci have been found, but the genes that cause familial prostate cancer remain largely elusive.

References:

[1]. Charles M Ewing, et al. Germline mutations in HOXB13 and prostate-cancer risk. N Engl J Med. 2012 Jan 12;366(2):141-9. [Content Brief]

[2]. Fredrik Wiklund, et al. Genetic analysis of the RNASEL gene in hereditary, familial, and sporadic prostate cancer. Clin Cancer Res. 2004 Nov 1;10(21):7150-6. [Content Brief]

[3]. Hong Lou, et al. Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibility. Proc Natl Acad Sci U S A. 2009 May 12;106(19):7933-8. [Content Brief]

[4]. T R Rebbeck, et al. Association of HPC2/ELAC2 genotypes and prostate cancer. Am J Hum Genet. 2000 Oct;67(4):1014-9. [Content Brief]

[5]. Veda N Giri, et al. Familial prostate cancer. Semin Oncol. 2016 Oct;43(5):560-565. [Content Brief]

[6]. Xiang Ao, et al. Association between EHBP1 rs721048(A>G) polymorphism and prostate cancer susceptibility: a meta-analysis of 17 studies involving 150,678 subjects. Onco Targets Ther. 2015 Jul 7;8:1671-80. [Content Brief]

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