Heterogeneous nuclear ribonucleoprotein L

Definition:

Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation.

References:

[1]. Anne Kruse Hollensen, et al. circZNF827 nucleates a transcription inhibitory complex to balance neuronal differentiation. Elife. 2020 Nov 11;9:e58478. [Content Brief]

[2]. Tiing Jen Loh, et al. hnRNP L inhibits CD44 V10 exon splicing through interacting with its upstream intron. Biochim Biophys Acta. 2015 Jun;1849(6):743-50. [Content Brief]

[3]. S Piñol-Roma, et al. A novel heterogeneous nuclear RNP protein with a unique distribution on nascent transcripts. J Cell Biol. 1989 Dec;109(6 Pt 1):2575-87. [Content Brief]

[4]. Ganesh Shankarling, et al. Transcriptome-wide RNA interaction profiling reveals physical and functional targets of hnRNP L in human T cells. Mol Cell Biol. 2014 Jan;34(1):71-83. [Content Brief]

[5]. David T Kuninger, et al. Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter. Nucleic Acids Res. 2002 Feb 1;30(3):823-9. [Content Brief]

[6]. Markus Blatter, et al. The Signature of the Five-Stranded vRRM Fold Defined by Functional, Structural and Computational Analysis of the hnRNP L Protein. J Mol Biol. 2015 Sep 25;427(19):3001-22. [Content Brief]

[7]. Guodong Liu, et al. A conserved serine of heterogeneous nuclear ribonucleoprotein L (hnRNP L) mediates depolarization-regulated alternative splicing of potassium channels. J Biol Chem. 2012 Jun 29;287(27):22709-16. [Content Brief]

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