Histone H4 transcription factor

Definition

Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter.

References:

[1]. Ricardo Medina, et al. The HiNF-P/p220NPAT cell cycle signaling pathway controls nonhistone target genes. Cancer Res. 2007 Nov 1;67(21):10334-42. [Content Brief]

[2]. Partha Mitra, et al. HiNF-P is a bifunctional regulator of cell cycle controlled histone H4 gene transcription. J Cell Biochem. 2007 May 1;101(1):181-91. [Content Brief]

[3]. Masayuki Sekimata, et al. Sequence-specific transcriptional repression by an MBD2-interacting zinc finger protein MIZF. Nucleic Acids Res. 2004 Jan 29;32(2):590-7. [Content Brief]

[4]. Partha Mitra, et al. Identification of HiNF-P, a key activator of cell cycle-controlled histone H4 genes at the onset of S phase. Mol Cell Biol. 2003 Nov;23(22):8110-23. [Content Brief]

[5]. Angela Miele, et al. HiNF-P directly links the cyclin E/CDK2/p220NPAT pathway to histone H4 gene regulation at the G1/S phase cell cycle transition. Mol Cell Biol. 2005 Jul;25(14):6140-53. [Content Brief]

[6]. M Sekimata, et al. Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2. J Biol Chem. 2001 Nov 16;276(46):42632-8. [Content Brief]

[7]. Ricardo Medina, et al. The histone gene cell cycle regulator HiNF-P is a unique zinc finger transcription factor with a novel conserved auxiliary DNA-binding motif. Biochemistry. 2008 Nov 4;47(44):11415-23. [Content Brief]

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