Ileal sodium/bile acid cotransporter

Definition:

Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Transports various bile acids, unconjugated or conjugated, such as cholate and taurocholate. Also responsible for bile acid transport in the renal proximal tubules, a salvage mechanism that helps conserve bile acids (Probable). Works collaboratively with the Na(+)-taurocholate cotransporting polypeptide (NTCP), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation.

References:

[1]. S A Weinman, et al. Bile acid uptake via the human apical sodium-bile acid cotransporter is electrogenic. J Biol Chem. 1998 Dec 25;273(52):34691-5. [Content Brief]

[2]. Roni F Kunst, et al. Targeting the Four Pillars of Enterohepatic Bile Salt Cycling; Lessons From Genetics and Pharmacology. Hepatology. 2021 Jun;73(6):2577-2585. [Content Brief]

[3]. A L Craddock, et al. Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter. Am J Physiol. 1998 Jan;274(1):G157-69. [Content Brief]

[4]. M H Wong, et al. Identification of a mutation in the ileal sodium-dependent bile acid transporter gene that abolishes transport activity. J Biol Chem. 1995 Nov 10;270(45):27228-34. [Content Brief]

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