Indoleamine 2,3-dioxygenase 2

Definition:

Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in immune regulation. May not play a significant role in tryptophan-related tumoral resistance.

References:

[1]. Nicolas van Baren, et al. Tryptophan-degrading enzymes in tumoral immune resistance. Front Immunol. 2015 Feb 3;6:34. [Content Brief]

[2]. Richard Metz, et al. Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan. Cancer Res. 2007 Aug 1;67(15):7082-7. [Content Brief]

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