Insulin-degrading enzyme

[1]. Nicolas Parmentier, et al. Production of an antigenic peptide by insulin-degrading enzyme. Nat Immunol. 2010 May;11(5):449-54. [Content Brief]

[2]. Luis A Ralat, et al. Insulin-degrading enzyme modulates the natriuretic peptide-mediated signaling response. J Biol Chem. 2011 Feb 11;286(6):4670-9. [Content Brief]

[3]. Yuequan Shen, et al. Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism. Nature. 2006 Oct 19;443(7113):870-4. [Content Brief]

[4]. W Q Qiu, et al. Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation. J Biol Chem. 1998 Dec 4;273(49):32730-8. [Content Brief]

[5]. Juan Pablo Maianti, et al. Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. Nature. 2014 Jul 3;511(7507):94-8. [Content Brief]

[6]. Zhening Zhang, et al. Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife. 2018 Mar 29;7:e33572. [Content Brief]

[7]. K Vekrellis, et al. Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme. J Neurosci. 2000 Mar 1;20(5):1657-65. [Content Brief]

[8]. Qingxue Li, et al. Insulin degrading enzyme is a cellular receptor mediating varicella-zoster virus infection and cell-to-cell spread. Cell. 2006 Oct 20;127(2):305-16. [Content Brief]

[9]. Ellen Hubin, et al. Characterization of insulin-degrading enzyme-mediated cleavage of Aβ in distinct aggregation states. Biochim Biophys Acta. 2016 Jun;1860(6):1281-90. [Content Brief]

[10]. Rebecca Deprez-Poulain, et al. Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice. Nat Commun. 2015 Sep 23;6:8250. [Content Brief]

[11]. Lauren A McCord, et al. Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13827-32. [Content Brief]

[12]. Qingxue Li, et al. The amino terminus of varicella-zoster virus (VZV) glycoprotein E is required for binding to insulin-degrading enzyme, a VZV receptor. J Virol. 2007 Aug;81(16):8525-32. [Content Brief]

[13]. Marika Manolopoulou, et al. Molecular basis of catalytic chamber-assisted unfolding and cleavage of human insulin by human insulin-degrading enzyme. J Biol Chem. 2009 May 22;284(21):14177-88. [Content Brief]

[14]. Hookang Im, et al. Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE. J Biol Chem. 2007 Aug 31;282(35):25453-63. [Content Brief]

[15]. Enrico Malito, et al. Molecular bases for the recognition of short peptide substrates and cysteine-directed modifications of human insulin-degrading enzyme. Biochemistry. 2008 Dec 2;47(48):12822-34. [Content Brief]

[16]. J A Affholter, et al. Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes. Mol Endocrinol. 1990 Aug;4(8):1125-35. [Content Brief]