Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]
Definition:
Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.
References:
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[1]. Min Lu, et al. Integrin alpha8beta1 mediates adhesion to LAP-TGFbeta1. J Cell Sci. 2002 Dec 1;115(Pt 23):4641-8. [Content Brief]
[2]. Eduardo Farias, et al. Integrin alpha8beta1-fibronectin interactions promote cell survival via PI3 kinase pathway. Biochem Biophys Res Commun. 2005 Apr 1;329(1):305-11. [Content Brief]
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