Interferon-stimulated gene 20 kDa protein

Definition:

Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single-stranded DNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) in an exonuclease-dependent manner. May also play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis.

References:

[1]. Zhi Zhou, et al. Antiviral activities of ISG20 in positive-strand RNA virus infections. Virology. 2011 Jan 20;409(2):175-88. [Content Brief]

[2]. L H Nguyen, et al. The human interferon- and estrogen-regulated ISG20/HEM45 gene product degrades single-stranded RNA and DNA in vitro. Biochemistry. 2001 Jun 19;40(24):7174-9. [Content Brief]

[3]. Lucile Espert, et al. Interferon-induced exonuclease ISG20 exhibits an antiviral activity against human immunodeficiency virus type 1. J Gen Virol. 2005 Aug;86(Pt 8):2221-2229. [Content Brief]

[4]. Lucile Espert, et al. ISG20, a new interferon-induced RNase specific for single-stranded RNA, defines an alternative antiviral pathway against RNA genomic viruses. J Biol Chem. 2003 May 2;278(18):16151-8. [Content Brief]

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