Kelch domain-containing protein 8B

Definition:

Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells.

References:

[1]. Maxwell M Krem, et al. Mitotic errors, aneuploidy and micronuclei in Hodgkin lymphoma pathogenesis. Commun Integr Biol. 2013 May 1;6(3):e23544. [Content Brief]

[2]. Maxwell M Krem, et al. Mutations in a gene encoding a midbody protein in binucleated Reed-Sternberg cells of Hodgkin lymphoma. Cell Cycle. 2010 Feb 15;9(4):670-5. [Content Brief]

[3]. Maxwell M Krem, et al. The kelch protein KLHDC8B guards against mitotic errors, centrosomal amplification, and chromosomal instability. J Biol Chem. 2012 Nov 9;287(46):39083-93. [Content Brief]

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