Ketosamine-3-kinase

Definition:

Ketosamine-3-kinase involved in protein deglycation by mediating phosphorylation of ribuloselysine and psicoselysine on glycated proteins, to generate ribuloselysine-3 phosphate and psicoselysine-3 phosphate, respectively. Ribuloselysine-3 phosphate and psicoselysine-3 phosphate adducts are unstable and decompose under physiological conditions. Not able to phosphorylate fructoselysine.

References:

[1]. François Collard, et al. Fructosamine 3-kinase-related protein and deglycation in human erythrocytes. Biochem J. 2004 Aug 15;382(Pt 1):137-43. [Content Brief]

[2]. François Collard, et al. A mammalian protein homologous to fructosamine-3-kinase is a ketosamine-3-kinase acting on psicosamines and ribulosamines but not on fructosamines. Diabetes. 2003 Dec;52(12):2888-95. [Content Brief]

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