Killer cell immunoglobulin-like receptor 2DS5

Definition

Activating natural killer (NK) receptor that recognizes C2 epitopes of HLA-C alleles. Bridging the innate and adaptive immune systems, NK cells express a number of cell surface receptors which either inhibit or stimulate their cytotoxicity. Able to activate NK cells citotoxicity and cytokine production such as IFNG. Receptor functions are attenuated even lost in some alleles, such as KIR2DS5*002 reprensented in this entry.

References:

[1]. Mariella Della Chiesa, et al. Evidence that the KIR2DS5 gene codes for a surface receptor triggering natural killer cell function. Eur J Immunol. 2008 Aug;38(8):2284-9. [Content Brief]

[2]. Noriko K Steiner, et al. Extracellular domain alterations impact surface expression of stimulatory natural killer cell receptor KIR2DS5. Immunogenetics. 2008 Nov;60(11):655-67. [Content Brief]

[3]. Jeroen H Blokhuis, et al. KIR2DS5 allotypes that recognize the C2 epitope of HLA-C are common among Africans and absent from Europeans. Immun Inflamm Dis. 2017 Dec;5(4):461-468. [Content Brief]

[4]. Noriko K Steiner, et al. Allelic variation of killer cell immunoglobulin-like receptor 2DS5 impacts glycosylation altering cell surface expression levels. Hum Immunol. 2014 Feb;75(2):124-8. [Content Brief]

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