Latent-transforming growth factor beta-binding protein 3
Definition:
Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta.
References:
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[1]. R Oklü, et al. The latent transforming growth factor beta binding protein (LTBP) family. Biochem J. 2000 Dec 15;352 Pt 3(Pt 3):601-10. [Content Brief]
[2]. J Saharinen, et al. Latent transforming growth factor-beta binding proteins (LTBPs)--structural extracellular matrix proteins for targeting TGF-beta action. Cytokine Growth Factor Rev. 1999 Jun;10(2):99-117. [Content Brief]
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