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  2. Major histocompatibility complex (MHC)/HLA proteins

Major histocompatibility complex (MHC)/HLA proteins

Definition:

Major histocompatibility complex (MHC)/HLA proteins are mediators of the T-lymphocyte responses. MHC comprises a family of surface proteins that regulate the adaptive immune system. The HLA comprises HLA classes I, II, III, as well as extended classes I and II sub-regions. This region is highly polygenic and polymorphic.

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