Membrane-bound transcription factor site-2 protease
Definition:
References:
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[1]. J Ye, et al. ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Mol Cell. 2000 Dec;6(6):1355-64. [Content Brief]
[2]. Uschi Lindert, et al. MBTPS2 mutations cause defective regulated intramembrane proteolysis in X-linked osteogenesis imperfecta. Nat Commun. 2016 Jul 6;7:11920. [Content Brief]
[3]. R B Rawson, et al. Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs. Mol Cell. 1997 Dec;1(1):47-57. [Content Brief]
[4]. J Ye, et al. Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5123-8. [Content Brief]
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