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Meniere disease

Definition:

Meniere disease is an inner ear disorder characterized by episodic vertigo attacks, sensorineural hearing loss, tinnitus, and aural fullness. Prevailing theories on its pathogenesis point to endolymphatic hydrops as one derangement responsible for producing dysfunction within the cochlea and peripheral vestibular apparatus. Although the familial clustering and the geographical and racial differences in incidence suggest a certain role for genetic factors in the development of Meniere disease, no convincing evidence for an association with any gene exists, at present.

References:

[1]. Akinobu Kakigi, et al. Antidiuretic hormone and osmolality in isosorbide therapy and glycerol test. ORL J Otorhinolaryngol Relat Spec. 2006;68(5):279-82. [Content Brief]

[2]. Giuseppe Chiarella, et al. The genetics of Ménière's disease. Appl Clin Genet. 2015 Jan 8;8:9-17. [Content Brief]

[3]. Matthew G Crowson, et al. A Systematic Review of Diuretics in the Medical Management of Ménière's Disease. Otolaryngol Head Neck Surg. 2016 May;154(5):824-34. [Content Brief]

[4]. Raanan Cohen-Kerem, et al. Intratympanic gentamicin for Menière's disease: a meta-analysis. Laryngoscope. 2004 Dec;114(12):2085-91. [Content Brief]

[5]. Seyed Javad Seyed Tootoonchi, et al. Hearing function after betahistine therapy in patients with Ménière's disease. Braz J Otorhinolaryngol. 2016 Sep-Oct;82(5):500-6. [Content Brief]

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