Antidiuretic hormone and osmolality in isosorbide therapy and glycerol test

  • ORL J Otorhinolaryngol Relat Spec. 2006;68(5):279-82. doi: 10.1159/000093299.
Akinobu Kakigi  1 ,  Taizo Takeda ,  Shoichi Sawada ,  Daizo Taguchi
Affiliations
  • 1. Department of Otolaryngology, Kochi Medical School, Nankoku, Kochi, Japan. [email protected]
PMID: 16699291 DOI: 10.1159/000093299
Abstract

Changes in plasma antidiuretic hormone (p-ADH) and plasma osmolality (p-Osm) levels were studied in 63 patients with Ménière's disease before and after isosorbide administration and a glycerol test. Increments in both p-ADH and p-Osm levels were observed after isosorbide administration and the glycerol test. The p-ADH secretion appeared to be secondarily stimulated by an increase in the p-Osm level. This p-ADH level increase affects cochlear fluid homeostasis. Based on these results, we must consider both the p-Osm and p-ADH levels when treating patients with Ménière's disease by osmotic diuretics.