Mitochondrial fission 1 protein

Definition:

Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.

References:

[1]. Dominic I James, et al. hFis1, a novel component of the mammalian mitochondrial fission machinery. J Biol Chem. 2003 Sep 19;278(38):36373-9. [Content Brief]

[2]. Oliver C Losón, et al. Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission. Mol Biol Cell. 2013 Mar;24(5):659-67. [Content Brief]

[3]. Annett Koch, et al. A role for Fis1 in both mitochondrial and peroxisomal fission in mammalian cells. Mol Biol Cell. 2005 Nov;16(11):5077-86. [Content Brief]

[4]. Diana Stojanovski, et al. Levels of human Fis1 at the mitochondrial outer membrane regulate mitochondrial morphology. J Cell Sci. 2004 Mar 1;117(Pt 7):1201-10. [Content Brief]

[5]. Sajjan Koirala, et al. Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission. Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):E1342-51. [Content Brief]

[6]. Tianzheng Yu, et al. Regulation of mitochondrial fission and apoptosis by the mitochondrial outer membrane protein hFis1. J Cell Sci. 2005 Sep 15;118(Pt 18):4141-51. [Content Brief]

[7]. Yisang Yoon, et al. The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1. Mol Cell Biol. 2003 Aug;23(15):5409-20. [Content Brief]

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