Mitochondrial Rho GTPase 1

Definition:

Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution. Promotes mitochondrial fission during high calcium conditions.

References:

[1]. Lianggong Ding, et al. Vimar Is a Novel Regulator of Mitochondrial Fission through Miro. PLoS Genet. 2016 Oct 7;12(10):e1006359. [Content Brief]

[2]. Asa Fransson, et al. Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. J Biol Chem. 2003 Feb 21;278(8):6495-502. [Content Brief]

[3]. Song Liu, et al. Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria. PLoS Genet. 2012;8(3):e1002537. [Content Brief]

[4]. Sa Fransson, et al. The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking. Biochem Biophys Res Commun. 2006 Jun 2;344(2):500-10. [Content Brief]

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