Mitochondrial translation release factor in rescue

Definition:

Part of a mitoribosome-associated quality control pathway that prevents aberrant translation by responding to interruptions during elongation. As heterodimer with MTRES1, ejects the unfinished nascent chain and peptidyl transfer RNA (tRNA), respectively, from stalled ribosomes. Recruitment of mitoribosome biogenesis factors to these quality control intermediates suggests additional roles for MTRES1 and MTRF during mitoribosome rescue.

References:

[1]. Nirupa Desai, et al. Elongational stalling activates mitoribosome-associated quality control. Science. 2020 Nov 27;370(6520):1105-1110. [Content Brief]

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