Mitochondrial tRNA methylthiotransferase CDK5RAP1
Definition:
References:
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[1]. Yick-Pang Ching, et al. Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor. J Biol Chem. 2002 May 3;277(18):15237-40. [Content Brief]
[2]. Veronika Reiter, et al. The CDK5 repressor CDK5RAP1 is a methylthiotransferase acting on nuclear and mitochondrial RNA. Nucleic Acids Res. 2012 Jul;40(13):6235-40. [Content Brief]
[3]. Md Fakruddin, et al. Cdk5rap1-mediated 2-methylthio-N6-isopentenyladenosine modification is absent from nuclear-derived RNA species. Nucleic Acids Res. 2017 Nov 16;45(20):11954-11961. [Content Brief]
[4]. Fan-Yan Wei, et al. Cdk5rap1-mediated 2-methylthio modification of mitochondrial tRNAs governs protein translation and contributes to myopathy in mice and humans. Cell Metab. 2015 Mar 3;21(3):428-42. [Content Brief]
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