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Moesin

Definition:

Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton. Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement. These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction. The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs. Modulates phagolysosomal biogenesis in macrophages (By similarity). Participates also in immunologic synapse formation.

References:

[1]. Iveta Iontcheva, et al. Role for moesin in lipopolysaccharide-stimulated signal transduction. Infect Immun. 2004 Apr;72(4):2312-20. [Content Brief]

[2]. Ana Urzainqui, et al. ITAM-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1. Immunity. 2002 Oct;17(4):401-12. [Content Brief]

[3]. Chantal Lagresle-Peyrou, et al. X-linked primary immunodeficiency associated with hemizygous mutations in the moesin (MSN) gene. J Allergy Clin Immunol. 2016 Dec;138(6):1681-1689.e8. [Content Brief]

[4]. J M Serrador, et al. CD43 interacts with moesin and ezrin and regulates its redistribution to the uropods of T lymphocytes at the cell-cell contacts. Blood. 1998 Jun 15;91(12):4632-44. [Content Brief]

[5]. J M Serrador, et al. Moesin interacts with the cytoplasmic region of intercellular adhesion molecule-3 and is redistributed to the uropod of T lymphocytes during cell polarization. J Cell Biol. 1997 Sep 22;138(6):1409-23. [Content Brief]

[6]. L Huang, et al. Replacement of threonine 558, a critical site of phosphorylation of moesin in vivo, with aspartate activates F-actin binding of moesin. Regulation by conformational change. J Biol Chem. 1999 Apr 30;274(18):12803-10. [Content Brief]

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