NT-3 growth factor receptor

Definition:

Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.

References:

[1]. Petra Werner, et al. Mutations in NTRK3 suggest a novel signaling pathway in human congenital heart disease. Hum Mutat. 2014 Dec;35(12):1459-68. [Content Brief]

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