Palmitoyltransferase ZDHHC18

Definition:

Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as CGAS, HRAS and LCK. Acts as a negative regulator of the cGAS-STING pathway be mediating palmitoylation and inactivation of CGAS. May also have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling.

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