country

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Penicillin-resistant Streptococcus pneumoniae infection

Definition:

Streptococcus pneumoniae is a common causative pathogen in community-acquired respiratory tract infections (RTIs), including acute otitis media, acute bacterial exacerbations of chronic bronchitis, acute bacterial sinusitis, and community-acquired pneumonia. It is also a major cause of bacteremia. Pneumococcal antibiotic resistance towards different families of antibiotics, in particular, penicillin and the macrocodes, continues to be a much-debated issue. The main mechanism of resistance in clinical isolates of S. pneumoniae involves the alteration of penicillin target proteins, the so-called penicillin binding protein (PBPs), which cause reduced affinities and/or binding capacities for the antibiotic molecule.

References:

[1]. Ana Maria Rivera, et al. Current concepts in antimicrobial therapy against select gram-positive organisms: methicillin-resistant Staphylococcus aureus, penicillin-resistant pneumococci, and vancomycin-resistant enterococci. Mayo Clin Proc. 2011 Dec;86(12):1230-43. [Content Brief]

[2]. Carlos Contreras-Martel, et al. PBP active site flexibility as the key mechanism for beta-lactam resistance in pneumococci. J Mol Biol. 2009 Apr 10;387(4):899-909. [Content Brief]

[3]. F Faella, et al. Combined treatment with ceftriaxone and linezolid of pneumococcal meningitis: a case series including penicillin-resistant strains. Clin Microbiol Infect. 2006 Apr;12(4):391-4. [Content Brief]

[4]. Javier Aspa, et al. Pneumococcal antimicrobial resistance: therapeutic strategy and management in community-acquired pneumonia. Expert Opin Pharmacother. 2008 Feb;9(2):229-41. [Content Brief]

[5]. Nicholas J Croucher, et al. Role of conjugative elements in the evolution of the multidrug-resistant pandemic clone Streptococcus pneumoniaeSpain23F ST81. J Bacteriol. 2009 Mar;191(5):1480-9. [Content Brief]

[6]. Nida Hameed, et al. Treatment of Drug-resistant Pneumococcal Meningitis. Curr Infect Dis Rep. 2010 Jul;12(4):274-81. [Content Brief]

[7]. R R Reinert, et al. The antimicrobial resistance profile of Streptococcus pneumoniae. Clin Microbiol Infect. 2009 Apr;15 Suppl 3:7-11. [Content Brief]

[8]. Stephen G Jenkins, et al. Trends in antibacterial resistance among Streptococcus pneumoniae isolated in the USA: update from PROTEKT US Years 1-4. Ann Clin Microbiol Antimicrob. 2008 Jan 11;7:1. [Content Brief]

Biomedical Dictionary

The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #