Phosphate-regulating neutral endopeptidase PHEX
Definition:
References:
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[1]. Rong Guo, et al. Inhibition of MEPE cleavage by Phex. Biochem Biophys Res Commun. 2002 Sep 13;297(1):38-45. [Content Brief]
[2]. M L Lipman, et al. Cloning of human PEX cDNA. Expression, subcellular localization, and endopeptidase activity. J Biol Chem. 1998 May 29;273(22):13729-37. [Content Brief]
[3]. Peter S N Rowe, et al. Surface plasmon resonance (SPR) confirms that MEPE binds to PHEX via the MEPE-ASARM motif: a model for impaired mineralization in X-linked rickets (HYP). Bone. 2005 Jan;36(1):33-46. [Content Brief]
[4]. William N Addison, et al. MEPE-ASARM peptides control extracellular matrix mineralization by binding to hydroxyapatite: an inhibition regulated by PHEX cleavage of ASARM. J Bone Miner Res. 2008 Oct;23(10):1638-49. [Content Brief]
[5]. Aline Martin, et al. Degradation of MEPE, DMP1, and release of SIBLING ASARM-peptides (minhibins): ASARM-peptide(s) are directly responsible for defective mineralization in HYP. Endocrinology. 2008 Apr;149(4):1757-72. [Content Brief]
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