Phosphatidylserine synthase 2

Definition

Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. Catalyzes the conversion of phosphatatidylethanolamine and does not act on phosphatidylcholine. Can utilize both phosphatidylethanolamine (PE) plasmalogen and diacyl PE as substrate and the latter is six times better utilized, indicating the importance of an ester linkage at the sn-1 position (By similarity). Although it shows no sn-1 fatty acyl preference, exhibits significant preference towards docosahexaenoic acid (22:6n-3) compared with 18:1 or 20:4 at the sn-2 position (By similarity).

References:

[1]. Shiho Tomohiro, et al. Purification and characterization of human phosphatidylserine synthases 1 and 2. Biochem J. 2009 Mar 1;418(2):421-9. [Content Brief]

生物医学辞典

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