Proepiregulin [Cleaved into: Epiregulin
Definition:
Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation. Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation.
References:
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[1]. David J Riese 2nd, et al. Epiregulin: roles in normal physiology and cancer. Semin Cell Dev Biol. 2014 Apr;28:49-56. [Content Brief]
[2]. T Komurasaki, et al. Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4. Oncogene. 1997 Dec 4;15(23):2841-8. [Content Brief]
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