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Proprotein convertase subtilisin/kexin type 5

Definition:

Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins.

References:

[1]. Sarah Paule, et al. Cleavage of endometrial α-integrins into their functional forms is mediated by proprotein convertase 5/6. Hum Reprod. 2012 Sep;27(9):2766-74. [Content Brief]

[2]. Sophea Heng, et al. Posttranslational activation of bone morphogenetic protein 2 is mediated by proprotein convertase 6 during decidualization for pregnancy establishment. Endocrinology. 2010 Aug;151(8):3909-17. [Content Brief]

[3]. Lynette M Kilpatrick, et al. Proteomic identification of caldesmon as a physiological substrate of proprotein convertase 6 in human uterine decidual cells essential for pregnancy establishment. J Proteome Res. 2009 Nov;8(11):4983-92. [Content Brief]

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