Protein lifeguard 4
Definition:
Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release.
References:
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[1]. Caroline Gubser, et al. A new inhibitor of apoptosis from vaccinia virus and eukaryotes. PLoS Pathog. 2007 Feb;3(2):e17. [Content Brief]
[2]. Fabrizio de Mattia, et al. Human Golgi antiapoptotic protein modulates intracellular calcium fluxes. Mol Biol Cell. 2009 Aug;20(16):3638-45. [Content Brief]
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