Putative protein-lysine deacylase ABHD14B

Definition

Acts as an atypical protein-lysine deacetylase in vitro. Catalyzes the deacetylation of lysine residues using CoA as substrate, generating acetyl-CoA and the free amine of protein-lysine residues. Additional experiments are however required to confirm the protein-lysine deacetylase activity in vivo (Probable). Has hydrolase activity towards various surrogate p-nitrophenyl (pNp) substrates, such as pNp-butyrate, pNp-acetate and pNp-octanoate in vitro, with a strong preference for pNp-acetate. May activate transcription.

References:

[1]. Abinaya Rajendran, et al. Functional Annotation of ABHD14B, an Orphan Serine Hydrolase Enzyme. Biochemistry. 2020 Jan 21;59(2):183-196. [Content Brief]

[2]. Balasundaram Padmanabhan, et al. The crystal structure of CCG1/TAF(II)250-interacting factor B (CIB). J Biol Chem. 2004 Mar 5;279(10):9615-24. [Content Brief]

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