Quinone oxidoreductase
Definition:
Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding.
References:
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[1]. M R Fernández, et al. Human and yeast zeta-crystallins bind AU-rich elements in RNA. Cell Mol Life Sci. 2007 Jun;64(11):1419-27. [Content Brief]
[2]. Andrea Lapucci, et al. zeta-Crystallin is a bcl-2 mRNA binding protein involved in bcl-2 overexpression in T-cell acute lymphocytic leukemia. FASEB J. 2010 Jun;24(6):1852-65. [Content Brief]
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