Ras GTPase-activating protein-binding protein 1

Definition

ATP- and magnesium-dependent helicase that plays an essential role in innate immunity. Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also RIGI-induced type I interferon production probably by helping RIGI at sensing pathogenic RNA. In addition, plays an essential role in stress granule formation. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR.

References:

[1]. Zhao-Shan Liu, et al. G3BP1 promotes DNA binding and activation of cGAS. Nat Immunol. 2019 Jan;20(1):18-28. [Content Brief]

[2]. Hideaki Matsuki, et al. Both G3BP1 and G3BP2 contribute to stress granule formation. Genes Cells. 2013 Feb;18(2):135-46. [Content Brief]

[3]. Helene Tourrière, et al. The RasGAP-associated endoribonuclease G3BP assembles stress granules. J Cell Biol. 2003 Mar 17;160(6):823-31. [Content Brief]

[4]. Shantá D Hinton, et al. The pseudophosphatase MK-STYX interacts with G3BP and decreases stress granule formation. Biochem J. 2010 Apr 14;427(3):349-57. [Content Brief]

[5]. Susana Soo-Yeon Kim, et al. The stress granule protein G3BP1 binds viral dsRNA and RIG-I to enhance interferon-β response. J Biol Chem. 2019 Apr 19;294(16):6430-6438. [Content Brief]

[6]. H Tourrière, et al. RasGAP-associated endoribonuclease G3Bp: selective RNA degradation and phosphorylation-dependent localization. Mol Cell Biol. 2001 Nov;21(22):7747-60. [Content Brief]

[7]. M Costa, et al. Human DNA helicase VIII: a DNA and RNA helicase corresponding to the G3BP protein, an element of the ras transduction pathway. Nucleic Acids Res. 1999 Feb 1;27(3):817-21. [Content Brief]

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