Rho GTPase-activating protein 32

Definition:

GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity).

References:

[1]. Sun Young Moon, et al. Characterization of a brain-specific Rho GTPase-activating protein, p200RhoGAP. J Biol Chem. 2003 Feb 7;278(6):4151-9. [Content Brief]

[2]. Tomoatsu Hayashi, et al. PX-RICS, a novel splicing variant of RICS, is a main isoform expressed during neural development. Genes Cells. 2007 Aug;12(8):929-39. [Content Brief]

[3]. Sachiko Taniguchi, et al. p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn. Biochem Biophys Res Commun. 2003 Jun 20;306(1):151-5. [Content Brief]

[4]. Chunmei Zhao, et al. GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2. J Biol Chem. 2003 Sep 5;278(36):34641-53. [Content Brief]

[5]. Takanobu Nakazawa, et al. p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-d-aspartate receptor signaling. Mol Biol Cell. 2003 Jul;14(7):2921-34. [Content Brief]

[6]. Toshio Okabe, et al. RICS, a novel GTPase-activating protein for Cdc42 and Rac1, is involved in the beta-catenin-N-cadherin and N-methyl-D-aspartate receptor signaling. J Biol Chem. 2003 Mar 14;278(11):9920-7. [Content Brief]

[7]. Takeshi Nakamura, et al. Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules. Mol Cell Biol. 2002 Dec;22(24):8721-34. [Content Brief]

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