Ribonuclease K6

Definition:

Ribonuclease which shows a preference for the pyrimidines uridine and cytosine. Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli. Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria. Probably contributes to urinary tract sterility. Bactericidal activity is independent of RNase activity.

References:

[1]. Brian Becknell, et al. Ribonucleases 6 and 7 have antimicrobial function in the human and murine urinary tract. Kidney Int. 2015 Jan;87(1):151-61. [Content Brief]

[2]. Guillem Prats-Ejarque, et al. The first crystal structure of human RNase 6 reveals a novel substrate-binding and cleavage site arrangement. Biochem J. 2016 Jun 1;473(11):1523-36. [Content Brief]

[3]. David Pulido, et al. Insights into the Antimicrobial Mechanism of Action of Human RNase6: Structural Determinants for Bacterial Cell Agglutination and Membrane Permeation. Int J Mol Sci. 2016 Apr 13;17(4):552. [Content Brief]

[4]. H F Rosenberg, et al. Molecular cloning and characterization of a novel human ribonuclease (RNase k6): increasing diversity in the enlarging ribonuclease gene family. Nucleic Acids Res. 1996 Sep 15;24(18):3507-13. [Content Brief]

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