RING-type E3 ubiquitin-protein ligase PPIL2

Definition:

Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation. May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity.

References:

[1]. S Hatakeyama, et al. U box proteins as a new family of ubiquitin-protein ligases. J Biol Chem. 2001 Aug 31;276(35):33111-20. [Content Brief]

[2]. Tatiana Pushkarsky, et al. Cell surface expression of CD147/EMMPRIN is regulated by cyclophilin 60. J Biol Chem. 2005 Jul 29;280(30):27866-71. [Content Brief]

[3]. Tara L Davis, et al. Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases. PLoS Biol. 2010 Jul 27;8(7):e1000439. [Content Brief]

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