Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

Definition

Rod-specific cGMP phosphodiesterase that catalyzes the hydrolysis of 3',5'-cyclic GMP. Necessary for the formation of a functional phosphodiesterase holoenzyme (By similarity). Involved in retinal circadian rhythm photoentrainment via modulation of UVA and orange light-induced phase-shift of the retina clock (By similarity). May participate in processes of transmission and amplification of the visual signal.

References:

[1]. Hakim Muradov, et al. Rod phosphodiesterase-6 PDE6A and PDE6B subunits are enzymatically equivalent. J Biol Chem. 2010 Dec 17;285(51):39828-34. [Content Brief]

[2]. M E McLaughlin, et al. Recessive mutations in the gene encoding the beta-subunit of rod phosphodiesterase in patients with retinitis pigmentosa. Nat Genet. 1993 Jun;4(2):130-4. [Content Brief]

生物医学辞典

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