S-acyl fatty acid synthase thioesterase, medium chain

Definition:

Contributes to the release of free fatty acids from fatty acid synthase (FASN). Has broad substrate specificity, giving rise to a range of free fatty acids with chain lengths between 10 and 16 carbon atoms (C10 - C16).

References:

[1]. Melissa K Ritchie, et al. Crystal Structure and Substrate Specificity of Human Thioesterase 2: INSIGHTS INTO THE MOLECULAR BASIS FOR THE MODULATION OF FATTY ACID SYNTHASE. J Biol Chem. 2016 Feb 12;291(7):3520-30. [Content Brief]

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