SCY1-like protein 2

Definition:

Component of the AP2-containing clathrin coat that may regulate clathrin-dependent trafficking at plasma membrane, TGN and endosomal system (Probable). A possible serine/threonine-protein kinase toward the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine has not been confirmed. By regulating the expression of excitatory receptors at synapses, plays an essential role in neuronal function and signaling and in brain development (By similarity).

References:

[1]. Michael Düwel, et al. Clathrin-dependent association of CVAK104 with endosomes and the trans-Golgi network. Mol Biol Cell. 2006 Oct;17(10):4513-25. [Content Brief]

[2]. Sean D Conner, et al. CVAK104 is a novel poly-L-lysine-stimulated kinase that targets the beta2-subunit of AP2. J Biol Chem. 2005 Jun 3;280(22):21539-44. [Content Brief]

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