Signal recognition particle receptor subunit alpha

Definition:

Component of the signal recognition particle (SRP) complex receptor (SR). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit SRP54. SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.

References:

[1]. Mario Halic, et al. Signal recognition particle receptor exposes the ribosomal translocon binding site. Science. 2006 May 5;312(5774):745-7. [Content Brief]

[2]. Jae Ho Lee, et al. Receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER. Sci Adv. 2021 May 21;7(21):eabg0942. [Content Brief]

[3]. Oliver Schlenker, et al. The structure of the mammalian signal recognition particle (SRP) receptor as prototype for the interaction of small GTPases with Longin domains. J Biol Chem. 2006 Mar 31;281(13):8898-906. [Content Brief]

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