Signal recognition particle subunit SRP68

Definition:

Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER. The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER. Binds the signal recognition particle RNA (7SL RNA), SRP72 binds to this complex subsequently. The SRP complex possibly participates in the elongation arrest function (By similarity).

References:

[1]. Elena Iakhiaeva, et al. Protein SRP68 of human signal recognition particle: identification of the RNA and SRP72 binding domains. Protein Sci. 2006 Jun;15(6):1290-302. [Content Brief]

[2]. Jae Ho Lee, et al. Receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER. Sci Adv. 2021 May 21;7(21):eabg0942. [Content Brief]

[3]. Matthias M M Becker, et al. Structures of human SRP72 complexes provide insights into SRP RNA remodeling and ribosome interaction. Nucleic Acids Res. 2017 Jan 9;45(1):470-481. [Content Brief]

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