Sin3 histone deacetylase corepressor complex component SDS3
Definition:
Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.
References:
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[1]. Suresh Ramakrishna, et al. Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity. J Biol Chem. 2011 Mar 25;286(12):10505-14. [Content Brief]
[2]. Tracey C Fleischer, et al. Identification and characterization of three new components of the mSin3A corepressor complex. Mol Cell Biol. 2003 May;23(10):3456-67. [Content Brief]
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