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Single Ig IL-1-related receptor

Definition:

Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.

References:

[1]. David Wald, et al. SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol. 2003 Sep;4(9):920-7. [Content Brief]

[2]. Venkatesh Sampath, et al. SIGIRR genetic variants in premature infants with necrotizing enterocolitis. Pediatrics. 2015 Jun;135(6):e1530-4. [Content Brief]

[3]. Jinzhong Qin, et al. SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms. J Biol Chem. 2005 Jul 1;280(26):25233-41. [Content Brief]

[4]. Nadia Polentarutti, et al. Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR. Eur Cytokine Netw. 2003 Oct-Dec;14(4):211-8. [Content Brief]

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