Small kinetochore-associated protein

Definition:

Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments. Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division. May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences.

References:

[1]. Lin Fang, et al. SKAP associates with kinetochores and promotes the metaphase-to-anaphase transition. Cell Cycle. 2009 Sep 1;8(17):2819-27. [Content Brief]

[2]. Yuejia Huang, et al. CENP-E kinesin interacts with SKAP protein to orchestrate accurate chromosome segregation in mitosis. J Biol Chem. 2012 Jan 6;287(2):1500-9. [Content Brief]

[3]. Anja K Dunsch, et al. The astrin-kinastrin/SKAP complex localizes to microtubule plus ends and facilitates chromosome alignment. J Cell Biol. 2011 Mar 21;192(6):959-68. [Content Brief]

[4]. Xiwei Wang, et al. Mitotic regulator SKAP forms a link between kinetochore core complex KMN and dynamic spindle microtubules. J Biol Chem. 2012 Nov 16;287(47):39380-90. [Content Brief]

[5]. Shan Lu, et al. Small kinetochore associated protein (SKAP) promotes UV-induced cell apoptosis through negatively regulating pre-mRNA processing factor 19 (Prp19). PLoS One. 2014 Apr 9;9(4):e92712. [Content Brief]

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